【現在投稿準備中の論文】 

 

・長期間心電図の臨床研究論文

 

・Leaky gutとinflammasome関連

 

 

 

43.

Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Toshiaki Ohara, Kazuya Kitamori, Ikumi Sato, Satoshi Hirohata, Moe Fujii, Shusei Yamamoto, Shang Ran, Shogo Watanabe, Experimental biology and medicine, in press, 2023.  

 

42.

SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses, Shusei Yamamoto, Koki Honma, Moe Fujii, Mai Kakimoto, Sora Kirihara, Hinako Nakayama, Kazuya Kitamori, Ikumi Sato, Satoshi Hirohata, Shogo Watanabe, Annals of anatomy, in press, 2023.

 

41.

Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model, Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoru Tamura, Minoru Ueda, Satoshi Hirohata, Shogo Watanabe, Canadian Journal of Physiology and Pharmacology, in press, 2023.

 

40.

Antioxidant Action of Xanthine Oxidase Inhibitor Febuxostat Protects the Liver and Blood Vasculature in SHRSP5/Dmcr Rat, Mai Kakimoto, Moe Fujii, Ikumi Sato, Koki Honma, Hinako Nakayama, Sora Kirihara, Taketo Fukuoka, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Shusei Yamamoto, Shogo Watanabe, Journal of Applied Biomedicine, in press, 2023.

 

39.

Uric acid elevation by fructose overload exacerbates NASH and atherosclerosis via oxidative stress, Moe Fujii, Mai Kakimoto, Ikumi Sato, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoshi Hirohata, Kazuya Kitamori, Shang Ran, Shusei Yamamoto, Shogo Watanabe, Current nutrition and food science, in press, 2023.

  

38. 

Glycine-conjugated and Unconjugated Bile Acid Levels Increased in SHRSP5/Dmcr Rat with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease, Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Natsumi Akiyama, Miku Sakai, Natsuki Fukuhama, Shota Kumazaki, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori, Shogo Watanabe, Acta medica okayama, in press, 2022.

 

37.

Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study, Inagaki, J., Nakano, A., Hatipoglu, O. F., Ooka, Y., Tani, Y., Miki, A., Ikemura, K., Opoku, G., Ando, R., Kodama, S., Ohtsuki, T., Yamaji, H., Yamamoto, S., Katsuyama, E., Watanabe, S. & Hirohata, S., International journal of molecular sciences, 23, 5, 2681, 2022.

 

36.

Suppression of Nitric Oxide Synthase Aggravates Non-alcoholic Steatohepatitis and Atherosclerosis in SHRSP5/Dmcr Rat via Acceleration of Abnormal Lipid Metabolism,  Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Shinichi Usui, Ryoko Shinohata, Kazuya Kitamori, Satoshi Hirohata, Shogo Watanabe, Pharmacological reports, 74 (4), 669-683, 2022

 

35.

A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression, Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui, Biochimie, 197: 49-58, 2022.

 

34.

Basic characteristics between mechanomyogram and muscle force during twitch and tetanic contractions in rat skeletal muscles, Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Satoshi Hirohata, Shogo Watanabe, Journal of Electromyography and Kinesiology, 62, 102627, 2022.

 

33.

Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial–mesenchymal transition, Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata, Biomedicine & Pharmacotherapy, 139, 111633, 2021

 

32.

ポータブル腸電位計と腹部エコーを用いた腸蠕動の 可視化と看護実践のイノベーション、前川 厚子、塩野 雅也、本田 育美、吉田 和枝、平野 明美、青山 京子、竹井 留美、渡邊 彰吾、渡辺 修、進藤 勝久、修文大学紀要、12、1-13、2020 

 

31.

Clinical importance of respiratory muscle fatigue in patients with cardiovascular disease, Taya, M., Amiya, E., Hatano, M., Saito, A., Nitta, D., Maki, H., Hosoya, Y., Minatsuki, S., Tsuji, M., Sato, T., Murakami, H., Narita, K., Konishi, Y., Watanabe, S., Yokota, K., Haga, N. & Komuro, I., Medicine, 99(34), e21794, 2020.

 

30.

Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome, Ryoko Shinohata, Yuhei Shiga, Shin-Ichiro Miura, Satoshi Hirohata, Misako Shibakura, Tomoe Ueno-Iio, Shogo Watanabe, Yujiro Arao, Shinichi Usui, Clinica Chimica Acta, 510, 531-536, 2020.

 

29.

Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model, Shusei Yamamoto, Ikumi Sato, Natsuki Fukuhama, Natsumi Akiyama, Miku Sakai, Shota Kumazaki, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori, Shogo Watanabe, Experimental and Molecular Pathology, 114,104437, 2020.

 

28. 

Bile acid metabolism is an intermediary factor between non-alcoholic steatohepatitis and ischemic heart disease in SHRSP5/Dmcr rats, Shota Kumazaki, Mayu Nakamura, Shun Sasaki, Rina Tagashira, Nozomi Maruyama, Ikumi Sato, Shusei Yamamoto, Shang Ran, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Kazuya Kitamori, Mari Mori, Yukio Yamori, Shogo Watanabe, Journal of Nutrition and Food Sciences, 9(4), 1-9, 2019.

 

27.

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model, S. Watanabe, S. Kumazaki, S. Yamamoto, I Sato, K. Kitamori, M. Mori, Y. Yamori, S. Hirohata, International Journal of Experimental Pathology, 99(6), 282-294, 2019.

 

26. 

A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats, S. Watanabe, S. Kumazaki, K. Kusunoki, T. Inoue, Y. Maeda, S. Usui, R. Shinohata, T. Ohtsuki, S. Hirohata, S. Kusachi, K. Kitamori, M. Mori, Y. Yamori, and H. Oka, Journal of Atherosclerosis and Thrombosis, 25(5), 439-453, 2018.

 

25. 

Novel mechanomyogram/electromyogram hybrid transducer measurements reflect muscle strength during dynamic exercise — Pedaling of recumbent bicycle, S. Fukuhara, S. Watanabe, H. Oka, Advanced Biomedical Engineering, 7, 47-54, 2018.

 

24. 

Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease, E. Amiya, M. Watanabe, S. Watanabe, M. Takata, I. Komuro, SpringerPlus, 5, 1103, 2017.

 

23. 

Estimating the minimum stimulation frequency necessary to evoke tetanic progression based on muscle twitch parameters, S. Watanabe, S. Fukuhara, T. Fujinaga and H. Oka, Physiological Measurement , 38, 466-476, 2017.

 

22. 

Electrically induced mechanomyograms reflect inspiratory muscle strength in young or elderly subjects, S. Watanabe, I. Nojima, Y. Agarie, T. Watanabe, S. Fukuhara, T. Fujinaga, H. Oka, Respiratory investigation, 54, 36-44, 2016.

 

21. 

Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats, K. Nagasawa, K. Takahashi, N. Matsuura, M. Takatsu, T. Hattori, S. Watanabe, E. Harada, K. Niinuma, T. Murohara, K. Nagata, Hypertension Research, 38 (1), 39-47, 2015.

 

20. 

Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome, N. Matsuura, C. Asano, K. Nagasawa, S. Ito, Y. Sano, Y. Minagawa, Y. Yamada, T. Hattori, S. Watanabe, T. Murohara, K. Nagata, International Journal of Cardiology, 179 (20), 360-369, 2015.

 

19. 

Roles of oxidative stress and the mineralocorticoid receptor in cardiac pathology in a rat model of metabolic syndrome , K. Takahashi, T. Murase, M. Takatsu, N. Matsuura, K. Nagasawa, T. Hattori, S. Watanabe, T. Murohara, K. Nagata, Nagoya Journal of Medical Science, 77 (1-2), 275-289, 2015.

 

18. 

Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome, N. Matsuura, K. Nagasawa, Y. Minagawa, S. Ito, Y. Sano, Y. Yamada, T. Hattori, S. Watanabe, T. Murohara, K. Nagata, American Journal of Physiology-Heart and Circulatory Physiology, 308(10), H1275-86, 2015.

 

17. 

Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome, Y. Takeshita, S. Watanabe, T. Hattori, K. Nagasawa, N. Matsuura, K. Takahashi, T. Murohara, K. Nagata, Hypertenssion Research, 38 (11), 741-750, 2015.

 

16.

Effect of Add-on Aliskiren to Type 1 Angiotensin Receptor Blocker Therapy on Endothelial Function and Autonomic Nervous System in Hypertensive Patients With Ischemic Heart Disease, Ozeki, A., Amiya, E., Watanabe, M., Hosoya, Y., Takata, M., Watanabe, A., Kawarasaki, S., Nakao, T., Watanabe, S., Omori, K., Yamada, N., Tahara, Y., Hirata, Y. & Nagai, R., Journal of clinical hypertension, 16(8), 591-598, 2014.

 

15.

Diurnal body temperature rise is reduced in diabetes with autonomic neuropathy, Amiya, E., Watanabe, M., Takata, M., Nakao, T., Hosoya, Y., Watanabe, S., Nagai, R. & Komuro, I., Clinical Autonomic Research, 24, 95-97, 2014.

 

14. 

Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome, T. Hattori, T. Murase, M. Takatsu, K. Nagasawa, N. Matsuura, S. Watanabe, T. Murohara, K. Nagata, Journal of Ammerican Heart Association, 3 (6), e001312, 2014.

 

13. 

Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation, S. Watanabe, E. Amiya, M. Watanabe, M. Takata, A. Ozeki, A. Watanabe, S. Kawarasaki, T. Nakao, Y. Hosoya, K. Nagata, R. Nagai, I. Komuro, PLoS One, 9 (10), e110013, 2014.

 

12. 

Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome, N. Takenaka-Ninagawa, Y. Kawabata, S. Watanabe, K. Nagata, S. Torihashi, PLoS One, 9(8), e104462, 2014. 

 

11. 

Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats, M. Ohtake, T. Hattori, T. Murase, K. Takahashi, M. Takatsu, M. Ohtake, M. Miyachi, S. Watanabe, X.W. Cheng, T. Murohara, K. Nagata, Nagoya Journal of Medical Science, 76(1-2), 59-72, 2014.

 

10. 

Premature cardiac senescence in DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome Takahashi K, Takatsu M, Hattori T, Murase T, Ohura S, Takeshita Y, Watanabe S, Murohara T, Nagata K, Nagoya Journal of Medical Science, 76(1-2), 35-49, 2014

 

9.

Differences in Body Temperature Variability Between Subjects With and Without Diabetes and Predictive Value for Cardiovascular Events, Eisuke Amiya, Masafumi Watanabe, Munenori Takata, Shogo Watanabe, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Yumiko Hosoya, Kazuko Omori, Koji Maemura, Yasunobu Hirata, Ryozo Nagai, Issei Komuro, Circulation Journal, 2013.

 

8.

Simultaneous heart rate variability monitoring enhances the predictive value of flow-mediated dilation in ischemic heart disease Watanabe Shogo, Amiya Eisuke, Watanabe Masafumi, Takata Munenori, Ozeki Atusko, Watanabe Aya, Kawarasaki Shuichi, Hosoya Yumiko, Nakao Tomoko, Ohmori Kazuko, Maemura Koji, Komuro Issei, Nagai Ryozo, Circulation Journal, 77(4), 1018-1025, 2012.

 

7.

The relationship between Fusion index - Frequency Curve of Displacement ? MMG and Fiber Composition of Skeletal Muscle、渡辺彰吾、北脇知己、岡久雄、バイオメカニズム、20、207-216、2010.

 

6.

Mathemaical equation of fusion index of tetanic contraction of skeletal muscles, Shogo WATANABE, Tomoki KITAWAKI, Hisao OKA, Journal of electromyography and kinesiology, 20, 284-289, 2009.

 

5.

New mathematical model of isometric twitch force-response curve by skeletal muscle contraction; using extended hybrid logistic model、北脇知己、渡辺彰吾、岡久雄、生体医工学、47(2)、199-208、2009.

 

4.

Consideration of Tetanic Contraction Properties of Different Skeletal Muscle Fibers Using Displacement MMG、渡辺彰吾、栗山雄樹、北脇知己、岡久雄、バイオメカニズム、19、23-33、2008.

 

3.

筋内圧力および生体表面の変位に着目した筋音図発生メカニズムの検討、渡辺彰吾、北脇知己、岡久雄、バイオメカニズム、18、209-218、2006.

 

2.

Muscle contraction accelerates IL-6 mRNA expression in the rat masseter muscle, Ono T, Maekawa K, Watanabe S, Oka H, Kuboki T, Archives of Oral Biology, 52(5), 479-486, 2007.

 

1.

局所筋機能測定のための筋内挿入型プローブの開発、岡久雄、枝松幹也、渡辺彰吾、北脇知己、岡山大学医学部保健学科紀要、16(1)、1-8、2005.